Workshop B – Cell Sorting to Manufacture TIL Products Enriched in Neoantigen-Reactive T Cells: What Are The Best Markers, Selection & Expansion Strategies?
Time: 12:00 pm
day: Pre-Conference Day
There are more bystander than tumor-reactive T cells infiltrating solid tumors, as well as in most TIL products administered to patients after conventional polyclonal expansion methods. Clinical-grade cell sorting combined with a better characterization of the phenotype of neoantigen-reactive T cells provide opportunities to manufacture more tumor-specific TIL products.
Join this collaborative session to:
• Consider which cell surface proteins best characterize neoantigenreactive CD8+ and CD4+ TILs in resected tumors
• Discuss whether selected CD4+ and CD8+ TILs should be expanded together or separately
• Decipher beside direct TIL selection from tumors, what are other relevant time points for TIL selection?
• Explore whether selected-TIL products are less relevant for melanoma?