Utilizing Multiplex CRISPR Gene Editing to Assess New Classes of Intra Cellular Immune Checkpoint Molecules for Application in TIL

Time: 12:00 pm
day: Day Two


• Comparing the function of CISH deletion relative to both extracellular and intracellular immune checkpoints in neoantigen cytolysis models

• Demonstrating intra-cellular immune checkpoint protein CISH can potentially enhance anti-tumor responses against a broad range of cancer types regardless of PD-L1 biomarker status

• Considering next generation checkpoints and the application to TIL