Are Tumor-Reactive TIL Really Exhausted or Can They Be Rescued For Adoptive T cell Therapy: Clinical Implications
Time: 2:00 pm
day: Day Two
Details:
• CD8 TIL that express both CD39 and CD103 are highly enriched for tumor reactivity and appear to have an exhausted phenotype
• The CD39/CD103 double CD8 TIL can be expanded into the billions during a 3-4 week expansion phase. Once expanded they have the capacity to kill tumors in vitro and in vivo and survive long-term in tumor-bearing hosts
